Systemic RNA Interference Deficiency-1 (SID-1) Extracellular Domain Selectively Binds Long Double-stranded RNA and Is Required for RNA Transport by SID-1

Abstract

Background: SystemicRNAinterference deficiency-1 (SID-1) is a membrane protein required for cellular uptake ofRNAin C. elegans. Results: SID-1 extracellular domain selectively binds long dsRNA. Conclusion: Binding affinity between SID-1 ECD and dsRNA is related to RNA transport efficiency by SID-1. Significance: This defines SID-1 ECD as a functional domain for dsRNA recognition.