Abdominal Aortic Aneurysm Rupture is not Associated with an Up-regulation of Inflammation within the Aneurysm Wall

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Abstract

Background: The nature of the inflammatory change within ruptured AAA has not been extensively reported. The aim of this study was to compare the inflammatory response in non-ruptured and ruptured aneurysms with emphasis on the site of rupture. Methods: Non-rupture site biopsies were taken from the anterior aneurysm sac of non-ruptured (n = 31) and ruptured AAA (n = 20). In 12 ruptured AAA, a further biopsy was taken from the rupture site. Enzyme-linked immunosorbent assay was used to quantify IL-6, IL-1beta and TNF-alpha. Quantitative immunohistochemistry was undertaken for generic lymphocytes, T-cells, and B-cells. Results: Comparing biopsies in non-ruptured AAA versus a non-rupture site biopsy from ruptured AAA; there was no significant difference in IL-6, IL-1β, TNF-alpha, generic lymphocytes, T-cell or B-cell content. Comparing ruptured AAA-non-rupture site with rupture site; IL-6 and TNF-alpha were unchanged. By contrast IL-1β and lymphocytes were lower at the rupture site compared to the non-rupture site (IL-1β 1.39 ng/mg [0.97-2.29] vs. 1.92 ng/mg [1.46-2.57], p = 0.027; generic lymphocytes 2.89% [0.51-5.51] vs. 4.73% [2.27-12.40], p = 0.018; T-cells 0.28% [0.04-1.18] vs. 0.82% [0.40-1.36], p = 0.027; B-cells 0.16% [0.04-1.14] vs. 1.30% [0.32-5.40], p = 0.021). Conclusions: These findings suggest the biological events leading to AAA rupture may not be dependent on an up-regulation in the inflammatory process. © 2010 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.

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Wilson, W. R. W., Wills, J., Furness, P. N., Loftus, I. M., & Thompson, M. M. (2010). Abdominal Aortic Aneurysm Rupture is not Associated with an Up-regulation of Inflammation within the Aneurysm Wall. European Journal of Vascular and Endovascular Surgery, 40(2), 191–195. https://doi.org/10.1016/j.ejvs.2010.04.014

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