Preparation of New α -aminophosphonate derivatives by kabachnik-fields reaction using a recyclable catalyst

Abstract

A convenient and efficient synthetic method for the preparation of some new α-aminophosphonate derivatives via a one-pot three-component system has been achieved using Amberlite IRC-748 as a recyclable catalyst. This method not only provides an excellent complement for the synthesis of α- aminophosphonates but also avoids the use of hazardous acids or expensive/toxic Lewis acids and harsh reaction conditions. Most of the synthesized compounds (4a-o) exhibited activity against bacteria/fungi strains and moderate DPPH radical scavenging activity. © 2013 Nellisara D. Shashikumar.