Abnormal cortical development after premature birth shown by altered allometric scaling of brain growth.

  • O K
  • S C
  • N K
  • et al.
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Abstract

We postulated that during ontogenesis cortical surface area and cerebral volume are related by a scaling law whose exponent gives a quantitative measure of cortical development. We used this approach to investigate the hypothesis that premature termination of the intrauterine environment by preterm birth reduces cortical development in a dose-dependent manner, providing a neural substrate for functional impairment.

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O, K., S, C., N, K., L, D., N, S., J, S., … A, E. (2006). Abnormal cortical development after premature birth shown by altered allometric scaling of brain growth. PLoS Medicine, 3(8), e265. Retrieved from http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1523379&tool=pmcentrez&rendertype=abstract

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