Abnormal kinetochore-generated pulling forces from Expressing a N-Terminally Modified Hec1

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Abstract

Highly Expressed in Cancer protein 1 (Hec1) is a constituent of the Ndc80 complex, a kinetochore component that has been shown to have a fundamental role in stable kinetochore-microtubule attachment, chromosome alignment and spindle checkpoint activation at mitosis. HEC1 RNA is found up-regulated in several cancer cells, suggesting a role for HEC1 deregulation in cancer. In light of this, we have investigated the consequences of experimentally-driven Hec1 expression on mitosis and chromosome segregation in an inducible expression system from human cells.

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Mattiuzzo, M., Vargiu, G., Totta, P., Fiore, M., Ciferri, C., Musacchio, A., & Degrassi, F. (2011). Abnormal kinetochore-generated pulling forces from Expressing a N-Terminally Modified Hec1. PLoS ONE, 6(1). https://doi.org/10.1371/journal.pone.0016307

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