Plasmodium falciparum artemisinin-resistant parasites can be evaluated by examining polymorphisms in the kelch ( PfK13 ) domain. A total of 69 samples from patients with falciparum malaria were analyzed. All samples were from areas in states in Brazil where the parasite was endemic: Acre ( n = 14), Amapá ( n = 15), Amazonas ( n = 30), and Pará ( n = 10). After DNA alignment with the 3D7 reference sequence, all samples were found to be wild type. These data provide a baseline for PfK13 and reinforce the pertinence of artemisinin combination therapy in Brazilian areas.
Gomes, L. R., Lavigne, A., Peterka, C. L., Brasil, P., Ménard, D., Daniel-Ribeiro, C. T., & Ferreira-da-Cruz, M. de F. (2018). Absence of K13 Polymorphism in Plasmodium falciparum from Brazilian Areas Where the Parasite Is Endemic . Antimicrobial Agents and Chemotherapy, 62(10). https://doi.org/10.1128/aac.00354-18