Absorption and metabolism of genistin in the isolated rat small intestine

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Abstract

Uptake and intestinal metabolism of physiologically active genistin were studied in an ex vivo intestinal perfusion model; luminally applied concentrations were 5.9, 12.0, and 23.8 μmol/l. The intestinal absorption of genistin was 14.9% (±2.3, n=9), irrespective of the amounts applied. The majority of the absorbed genistin appeared as genistein glucuronide (11.6%), also recovered as the main metabolite on the luminal side (19.5%). Minor amounts of genistin (1.3%) and genistein (1.9%) were found on the vascular side, whereas 15.4% of applied genistin was luminally cleaved to yield genistein. Sulfate derivatives of genistein or genistin were not observed. Copyright (C) 2000 Federation of European Biochemical Societies.

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Andlauer, W., Kolb, J., & Fürst, P. (2000). Absorption and metabolism of genistin in the isolated rat small intestine. FEBS Letters, 475(2), 127–130. https://doi.org/10.1016/S0014-5793(00)01642-2

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