Melatonin effects on pulmonary tissue in the experimental model of hepatopulmonary syndrome

8Citations
Citations of this article
15Readers
Mendeley users who have this article in their library.

Abstract

Objective: To evaluate the pulmonary alterations of animals with Hepatopulmonary Syndrome (HPS) submitted to Biliary Duct Ligature (BDL), as well as the antioxidant effect of Melatonin (MEL). Methods: Sixteen male Wistar rats, divided into four Sham groups: BDL group, Sham + MEL group and BDL + MEL. The pulmonary and hepatic histology, lipoperoxidation and antioxidant activity of lung tissue, alveolar-arterial O2 difference and lung/body weight ratio (%) were evaluated. Results: When comparing the groups, could be observed an increase of vasodilation and pulmonary fibrosis in the BDL group and the reduction of this in relation to the BDL + MEL group. It was also observed significant changes in the activity of catalase, ApCO2, ApO2 in the LBD group when compared to the other groups. Conclusion: The use of MEL has been shown to be effective in reducing vasodilation, fibrosis levels and oxidative stress as well as gas exchange in an experimental HPS model.

Cite

CITATION STYLE

APA

Bosco, A. D., Schedler, F. B., Colares, J. R., Schemitt, E. G., Hartmann, R. M., Forgiarini Junior, L. A., … Marroni, N. P. (2019). Melatonin effects on pulmonary tissue in the experimental model of hepatopulmonary syndrome. Jornal Brasileiro de Pneumologia, 45(3). https://doi.org/10.1590/1806-3713/e20170164

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free