Abstract
We evaluated the in vivo antischistosomal activities of 11 structurally diverse synthetic peroxides. Of all compounds tested, ozonide (1,2,4-trioxolane) OZ418 had the highest activity against adult Schistosoma mansoni, with total and female worm burden reductions of 80 and 90% (P<0.05), respectively. Furthermore, treatment of S. haematobium-infected mice with OZ418 reduced the total worm burden by 86%. In conclusion, OZ418 is a promising antischistosomal lead compound. Copyright © 2012, American Society for Microbiology. All Rights Reserved.
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CITATION STYLE
Keiser, J., Ingram, K., Vargas, M., Chollet, J., Wang, X., Dong, Y., & Vennerstrom, J. L. (2012). In vivo activity of aryl ozonides against Schistosoma species. Antimicrobial Agents and Chemotherapy, 56(2), 1090–1092. https://doi.org/10.1128/AAC.05371-11
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