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Park et al. demonstrate that >50% of human breast tumors exhibit an alteration in one of the splicing factors from the SR protein family. Using in vitro and in vivo breast cancer models, they identify three splicing factors that promote cell proliferation and invasion by regulating isoforms associated with cancer hallmarks.
Park, S. H., Brugiolo, M., Akerman, M., Das, S., Urbanski, L., Geier, A., … Anczuków, O. (2019). Differential Functions of Splicing Factors in Mammary Transformation and Breast Cancer Metastasis. Cell Reports, 29(9), 2672-2688.e7. https://doi.org/10.1016/j.celrep.2019.10.110