Receptor tyrosine kinase-like orphan receptor 2 (Ror2) expression creates a poised state of wnt signaling in renal cancer

Abstract

Background: Expression of Ror2 leads to increased tumorigenicity in RCC. Results: Ror2 expression stabilizes an increased pool of soluble β-catenin, which enhances the response to Wnt stimulation. Conclusion: Ror2 promotes basal and canonical Wnt3a ligand-enhanced β-catenin signaling in RCC. Significance: This work demonstrates a novel Ror2-dependent tiered state of canonical Wnt signaling, promoting basal signals and priming RCC cells for a heightened response to the ligand. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.