A computer-based differential display tool named HsAnalyst has been developed and successfully used for the comparison of expression patterns in a set of tumours versus a set of normal tissues. A list of EST clusters highly represented in tumours and rarely observed in normal tissues has been developed as a resulting output file of the program. These differentially expressed EST clusters (genes) can be useful for developing new tumour markers and prognostic indicators for a wide set of human malignancies. Tumour-specific protein-coding genes may be considered a manifestation of tumour-specific gene expression. © 2001 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.
Baranova, A. V., Lobashev, A. V., Ivanov, D. V., Krukovskaya, L. L., Yankovsky, N. K., & Kozlov, A. P. (2001). In silico screening for tumour-specific expressed sequences in human genome. FEBS Letters, 508(1), 143–148. https://doi.org/10.1016/S0014-5793(01)03028-9