Recent studies have revealed remarkable species specificity of the Toll-like receptors (TLRs) TLR11 and TLR12 and the immunity-related GTPase (IRG) proteins that are essential elements for detection and immune control of Toxoplasma gondii in mice, but not in humans. The biological and evolutionary implications of these findings for the T. gondii host-pathogen relationship and for human disease are discussed. © 2014 Elsevier Inc.
Gazzinelli, R. T., Mendonça-Neto, R., Lilue, J., Howard, J., & Sher, A. (2014, February 12). Innate resistance against Toxoplasma gondii: An evolutionary tale of mice, cats, and men. Cell Host and Microbe. Cell Press. https://doi.org/10.1016/j.chom.2014.01.004