Cytokines and cell adhesion molecules exhibit distinct profiles in health, ovarian cancer, and breast cancer

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Abstract

Objective We examined a panel of cytokines and cell adhesion molecules in an attempt to identify cancer specific profiles. Design and methods Cytokines and cell adhesion arrays (Randox Ltd.) were measured in samples from women with a histological diagnosis of ovarian cancer (n=42) or breast cancer (n=60) or cancer free (n=32). Random forest analysis was used for classification. Results Ovarian cancer subjects were classified with a sensitivity of 85.7% (95% CI 50-100) and a specificity of 84.2% (95% CI 69.4-93.4). Breast cancer subjects were classified with a sensitivity of 70.8% (95% CI 47.1-86.4) and a specificity of 96.4% (95% CI 82.1-100). Discussion Cytokine and cell adhesion molecule profiles provide additional information that may be useful for cancer characterization of female cancers.

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Henderson, M. P. A., Hirte, H., Hotte, S. J., & Kavsak, P. A. (2016). Cytokines and cell adhesion molecules exhibit distinct profiles in health, ovarian cancer, and breast cancer. Heliyon, 2(1). https://doi.org/10.1016/j.heliyon.2015.e00059

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