Networks of the cytoskeletal biopolymer actin cross-linked by the compliant protein filamin form soft gels that stiffen dramatically under shear stress. We demonstrate that the elasticity of these networks shows a strong dependence on the mean length of the actin polymers, unlike networks with small, rigid cross-links. This behavior is in agreement with a model of rigid filaments connected by multiple flexible linkers. © 2010 by the Biophysical Society.
Kasza, K. E., Broedersz, C. P., Koenderink, G. H., Lin, Y. C., Messner, W., Millman, E. A., … Weitz, D. A. (2010). Actin filament length tunes elasticity of flexibly cross-linked actin networks. Biophysical Journal, 99(4), 1091–1100. https://doi.org/10.1016/j.bpj.2010.06.025