Activation of melanogenesis by vacuolar type H+-ATPase inhibitors in amelanotic, tyrosinase positive human and mouse melanoma cells

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Abstract

In this study, we describe the activation of melanogenesis by selective vacuolar type H+-ATPase inhibitors (bafilomycin A1 and concanamycin A) in amelanotic human and mouse melanoma cells which express tyrosinase but show no melanogenesis. Addition of the inhibitors activated tyrosinase within 4 h, and by 24 h the cells contained measurable amounts of melanin. These effects were not inhibited by cycloheximide (2 μg/ml) which is consistent with a post-translational mechanism of activation. Our findings suggest that melanosomal pH could be an important and dynamic factor in the control of melanogenesis in mammalian cells. Copyright (C) 2000 Federation of European Biochemical Societies.

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Ancans, J., & Thody, A. J. (2000). Activation of melanogenesis by vacuolar type H+-ATPase inhibitors in amelanotic, tyrosinase positive human and mouse melanoma cells. FEBS Letters, 478(1–2), 57–60. https://doi.org/10.1016/S0014-5793(00)01795-6

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