Acute Coronary Syndromes: Differences in Men and Women

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Purpose of Review Increased awareness of cardiovascular dis-ease in women has prompted studies to investigate gender-related disparities in acute coronary syndromes (ACSs). In this review, we discuss findings from current literature on the clin-ical presentation, pathophysiology, diagnosis, and manage-ment of ACS in women as compared to men. Recent Findings Emerging data show that cardiovascular dis-ease (CVD) continues to be the leading cause of death in women and the annual mortality rate from CVD remains higher in women compared to men. Recent studies demon-strate sex-specific differences in patients presenting with ACS. Comorbidities, especially diabetes, are more common in young women compared with age-matched men who de-velop acute myocardial infarction (AMI). Women are more likely to have atypical symptoms and nonobstructive coronary disease on angiography. Women are less likely to receive guideline-based therapies. They have higher rates of peri-procedural complications with PCI and are less likely to be referred to cardiac rehabilitation. Summary Awareness of differences in the underlying patho-physiology of coronary disease in women compared to men may lead to improved gender-based diagnostic and treatment modalities. However, until more studies are performed, efforts should be directed toward improving delivery of current, gender-neutral guidelines in women just as in men.




Kawamoto, K. R., Davis, M. B., & Duvernoy, C. S. (2016, December 1). Acute Coronary Syndromes: Differences in Men and Women. Current Atherosclerosis Reports. Current Medicine Group LLC 1.

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