Acute liver failure: A curable disease by 2024?

60Citations
Citations of this article
115Readers
Mendeley users who have this article in their library.

Abstract

Over the last three decades acute liver failure (ALF) has been transformed from a rare and poorly understood condition with a near universally fatal outcome, to one with a well characterized phenotype and disease course. Complex critical care protocols are now applied and emergency liver transplantation (ELT) is an established treatment option. These improvements in care are such that the majority of patients may now be expected to survive (Fig. 1). Key features of the condition have changed dramatically over time, with a remarkable fall in the incidence of cerebral edema and intracranial hypertension, a much feared complication. In this review, we summarize the current understanding of key aspects of the classification, pathophysiology and management of ALF, and discuss the foreseeable challenges that will need to be addressed for further improvements to be achieved.

Cite

CITATION STYLE

APA

Bernal, W., Lee, W. M., Wendon, J., Larsen, F. S., & Williams, R. (2015). Acute liver failure: A curable disease by 2024? Journal of Hepatology. Elsevier. https://doi.org/10.1016/j.jhep.2014.12.016

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free