Molecular Significance of lon and cpxR Genes in the Pathogenicity of Salmonella

Abstract

The important foodborne zoonotic pathogen Salmonella causes gastroenteritis. The dynamics of host-pathogen Salmonella interaction and infection might enhance the development of novel targeted preventative measures and drug regimens. The lon and cpxR are virulence associated genes, which have an important role in the Salmonella pathogenesis. However, the deletions of lon and cpxRlead to the construction of genetically engineered live Salmonella vaccine candidate. In this review, lon and cpxR genes are focused for their involvement in Salmonella pathogenesis. Furthermore, the importance of these genes was briefly emphasized during the construction of Salmonella vaccine candidate.