Association of epstein-barr virus (EBV) but not human papillomavirus (hpv) with gingivitis and/or periodontitis in transplanted individuals

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Abstract

The aim of this study was to investigate the association of EBV and HPV with gingivitis and/or periodontitis according to the immunologic status. To this end, 74 oral biopsies from transplanted and non-transplanted individuals with the abovementioned oral manifestations were submitted to a screening by PCR for both viruses. According to the results, EBV was strongly associated with gingivitis and/or periodontitis in transplanted individuals (p = 0.011) but not HPV (p = 0.766). EBV-HPV co-detections did not enhance the presence of tissue injury as well. Although a causal relationship was not investigated in this study, the higher frequency of these two oncoviruses in lesion tissues must be investigated in follow-up studies, especially among immunocompromised individuals.

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Baez, C. F., Savassi-Ribas, F., Da Rocha, W. M., Almeida, S. G. S., Gonçalves, M. T. V., Guimarães, M. A. A. M., … Varella, R. B. (2016). Association of epstein-barr virus (EBV) but not human papillomavirus (hpv) with gingivitis and/or periodontitis in transplanted individuals. Revista Do Instituto de Medicina Tropical de Sao Paulo, 58. https://doi.org/10.1590/S1678-9946201658058

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