The activity of transport system A for neutral amino acids is adaptively stimulated upon amino acid starvation. In cultured human fibroblasts this treatment causes an increase in the expression of the ATA2 system A transporter gene. ATA2 mRNA increase and transport stimulation are suppressed by system A substrates, but they are unaffected by other amino acids. Supplementation of amino acid-starved cells with substrates of system A causes a decrease in both ATA2 mRNA and system A transport activity. These results suggest a direct relationship between ATA2 expression and system A transport activity. © 2001 Federation of European Biochemical Societies.
Franchi Gazzola, R., Sala, R., Bussolati, O., Visigalli, R., Dall’Asta, V., Ganapathy, V., & Gazzola, G. C. (2001). The adaptive regulation of amino acid transport system A is associated to changes in ATA2 expression. FEBS Letters, 490(1–2), 11–14. https://doi.org/10.1016/S0014-5793(01)02126-3