In human pregnancy, a correct placentation depends on trophoblast proliferation, differentiation, migration and invasion. These processes are highly regulated by placental hormones, growth factors and cytokines. Recently, we have shown that adiponectin, an adipokine, has anti-proliferative effects on trophoblastic cells. Here, we complete this study by demonstrating that adiponectin modulates BeWo and human villous cytotrophoblast cell differentiation.
Benaitreau, D., Santos, E. D., Leneveu, M. C., De Mazancourt, P., Pecquery, R., & Dieudonné, M. N. (2010). Adiponectin promotes syncytialisation of BeWo cell line and primary trophoblast cells. Reproductive Biology and Endocrinology, 8. https://doi.org/10.1186/1477-7827-8-128