Adipose derived stem cells (ASC) in wound healing: Recent results in vitro and in vivo

  • Fromm-Dornieden C
  • Koenen P
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Abstract

Introduction Chronic wounds represent a major problem in medicine today as their incidence is continuously increas- ing due to an ageing population and a rise in the incidence of underlying diseases. Cutaneous wound healing is a complex biological process. Chronic wounds are characterised by a prolonged inflammation, persistent infections, formation of drug- resistant microbial biofilms and the inability of dermal and/or epidermal cells to respond to regenerative stimuli. As conventional treatment strat- egies often fail, innovative therapies have been investigated over the last decade, including stem cell-based therapies. After the initial use of embryonic stem cells, the focus has been set on autologous mesenchymal stem cells over the past years. They can be isolated in large amounts from various tissues and hold no ethical con- cerns. A promising and cost-effective source of autologous mesenchymal stem cells is subcutaneous adipose tissue. Recent in vitro and in vivo studies have shown that adipose- derived stem cells have a positive impact on wound healing, as they are attracted to the wound site and influence regeneration processes via paracrine mechanisms. They are pluripotent and secrete a variety of growth factors. The aim of this critical review was to discuss adipose- derived stem cells in wound healing. Conclusion Mesenchymal stem cells-derived from adipose tissue are a promis- ing alternative to embryonic or bone marrow-derived stem cells in the therapy of chronic wounds. Because the use of adipose-derived stem cells in wound healing applications is still limited by a lack of clinical data, further studies have to pave the way for their routine clinical application. Introduction

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Fromm-Dornieden, C., & Koenen, P. (2013). Adipose derived stem cells (ASC) in wound healing: Recent results in vitro and in vivo. OA Molecular and Cell Biology, 1(1). https://doi.org/10.13172/2054-7331-1-1-1147

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