Synthesis of Novel a-Amino Acids Bearing 1,2,4-triazinone and Steroidal Moieties as Enzymetic Affect (Cellobiase Activity) Part I

Abstract

An imperative class of α-amino acids bearing 1,2,4-triazinone and N,C-disubstituted glycine (5a,b) and/or the related systems (6 and 7) have been synthesized by the condensation of 6-(2'-aminophenyl-4-phenyl-3-thion -1,2,4-triazin-5-one (1) with the appropriate steroids, Epiandrosteron (2a) and Dehydrosterone (2b), followed by the addition of hydrocyanic acid. Nucleophilic substitution of mercapto group of (5) by 4-fluoroaniline and sulfanilamide give the corresponding systems 6 and 7. Compounds 6,7, 5, and 4 showed a high enzymatic effect as cellobiase agents against some tested fungi .