LBP and CD14 polymorphisms correlate with increased colorectal carcinoma risk in Han Chinese

Abstract

AIM: To explore the associations of polymorphismsof lipopolysaccharide binding protein (LBP), cluster ofdifferentiation 14 (CD14), toll-like receptor 4 (TLR-4),interleukin-6 (IL-6) and tumor necrosis factor α (TNF-α)with the colorectal carcinoma (CRC) risk in Han Chinese.METHODS: Polymorphisms of LBP (rs1739654, rs2232596,rs2232618), CD14 (rs77083413, rs4914), TLR-4(rs5030719), IL-6 (rs13306435) and TNF-α (rs35131721)were genotyped in 479 cases of sporadic colorectalcarcinoma and 486 healthy controls of Han Chinese ina case-control study. Single-nucleotide polymorphisms(SNPs) between cases and controls were analyzed byunconditional logistic regression.RESULTS: GA and GG genotypes of LBP rs2232596were associated with a significantly increased risk ofCRC [odds ratio (OR) = 1.51, 95% confidence interval(CI) 1.15-1.99, P = 0.003; OR = 2.49, 95% CI 1.16-5.38,P = 0.016, respectively]. A similar association was alsoobserved for the CG genotype of CD14 rs4914 (OR=1.69, 95% CI 1.20-2.36, P = 0.002). In addition, a combinationof polymorphisms in LBP rs2232596 and CD14rs4914 led to a 3.4-fold increased risk of CRC (OR = 3.44,95% CI 1.94-6.10, P = 0.000).CONCLUSION: This study highlights the LBP rs2232596and CD14 rs4914 polymorphisms as biomarkers for elevatedCRC susceptibility in the Chinese Han population. © 2011 Baishideng. All rights reserved.