A new chemical approach to human ABO Histo-Blood group Type 2 antigens

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Abstract

A new chemical approach to synthesizing human ABO histo-blood type 2 antigenic determinants was developed. N-Phthaloyl-protected lactosaminyl thioglycoside derived from lactulose via the Heyns rearrangement was employed to obtain a type 2 core disaccharide. Use of this scheme lowered the overall number of reaction steps. Stereoselective construction of the a-galactosaminide/galactoside found in A- and B-Antigens, respectively, was achieved by using a unique di-tert-butylsilylene-directed a-glycosylation method. The proposed synthetic scheme provides an alternative to existing procedures for preparing ABO blood group antigens.© 2014 by the authors licensee MDPI Basel Switzerland.

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Hara, A., Imamura, A., Ando, H., Ishida, H., & Kiso, M. (2014). A new chemical approach to human ABO Histo-Blood group Type 2 antigens. Molecules, 19(1), 414–437. https://doi.org/10.3390/molecules19010414

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