Inhibitory Effect of Neem Leaves on Glucose Transport

  • Johansyah L
  • Yunivita V
  • Martiana A
  • et al.
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Abstract

The carrier-mediated glucose transport function in the intact human erythrocytes and also that of their isolated membranes is markedly inhibited in the presence of furosemide in vitro. A noncompetitive process is believed to be involved since the transport inhibition was not affected by the presence of high concentrations of glucose in the medium. The inhibition developed slowly over 2 hours. Most of the inhibition was slowly reversed during a 3-hour incubation in medium free of the drug. It is concluded that furosemide inhibits the glucose transport function directly in absence of insulin-mediated transduction mechanism and independently of any interference with intracellular glycolysis. © 1976.

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Johansyah, L. S., Yunivita, V., Martiana, A., & Arifin, A. Y. L. (2018). Inhibitory Effect of Neem Leaves on Glucose Transport. Althea Medical Journal, 5(4), 192–195. https://doi.org/10.15850/amj.v5n4.501

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