Global and regional changes in cortical development assessed by MRI in fetuses with isolated nonsevere ventriculomegaly correlate with neonatal neurobehavior

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Abstract

BACKGROUND AND PURPOSE: Fetuses with isolated nonsevere ventriculomegaly (INSVM) are at risk of presenting neurodevelopmental delay. However, the currently used clinical parameters are insufficient to select cases with high risk and determine whether subtle changes in brain development are present and might be a risk factor. The aim of this study was to perform a comprehensive evaluation of cortical development in INSVM by magnetic resonance (MR) imaging and assess its association with neonatal neurobehavior. MATERIALSANDMETHODS: Thirty-two INSVM fetuses and 29 healthy controls between 26-28 weeks of gestation were evaluated using MR imaging. We compared sulci and fissure depth, cortical maturation grading of specific areas and sulci and volumes of different brain regions obtained from 3D brain reconstruction of cases and controls. Neonatal outcome was assessed by using the Neonatal Behavioral Assessment Scale at a mean of 4 ± 2 weeks after birth. RESULTS: Fetuses with INSVM showed less profound and underdeveloped sulcation, including the Sylvian fissure (mean depth: Controls 16.8 ± 1.9 mm, versus INSVM 16.0 ± 1.6 mm; P = .01), and reduced global cortical grading (mean score: Controls 42.9 ± 10.2 mm, versus INSVM: 37.8 ± 9.9 mm; P = .01). Fetuses with isolated nonsevere ventriculomegaly showed a mean global increase of gray matter volume (controls, 276.8±46.0±10mm3, versus INSVM 277.5±49.3±10mm3, P=.01), but decreased mean cortical volume in the frontal lobe (left: Controls, 53.2±8.8×10 mm3, versus INSVM 52.4±5.4×10 mm3; P=

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APA

Hahner, N., Benkarim, O. M., Aertsen, M., Perez-Cruz, M., Piella, G., Sanroma, G., … Eixarch, E. (2019). Global and regional changes in cortical development assessed by MRI in fetuses with isolated nonsevere ventriculomegaly correlate with neonatal neurobehavior. In American Journal of Neuroradiology (Vol. 40, pp. 1567–1574). American Society of Neuroradiology. https://doi.org/10.3174/ajnr.A6165

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