Microwave-assisted synthesis of potent antimicrobial agents of flavanone derivatives

Abstract

The currently available antimicrobial drugs suffer from toxicity, interactions with other drugs, insufficient pharmacokinetic properties, and the development of resistance. Thus, development of new antimicrobial agents with optimum pharmacokinetics and low toxicity is important. In this study, a series of flavanone, hydrazone derivatives have been prepared from flavanone under microwave irradiation after a very short reaction time (1-2 min.) with good yields. The structures of the synthesized compounds were elucidated using various spectroscopic methods. The screening of the synthesized compounds for antimicrobial activity was performed against Staphylococcus aureus, Escherichia coli , C. Albicans and Aspergillus niger. Some of the synthesized compounds show potent anti microbial activity. Microwave irradiation Flavanone Hydrazone Isoniazide Antimicrobial activity.