High stereoselective cyclopropanation reaction of 3-acylcoumarins with α-bromoketones at room temperature

Abstract

Reaction of 3-acylcoumarins with α-bromoketones in the presence of a base give the cyclopropane derivatives in good stereoselectivity and moderate yield. The reaction was carried out at room temperature in mixed solvents without exclusion of moisture or air. © Indian Academy of Sciences.