Direct measurement of the sensitized luminescence of the europium-ciprofloxacin chelate immobilized on a cationic exchanger was used to develop a flow-through room-temperature phosphorescence optosensor for determination of ciprofloxacin. The phosphorescent chelate is formed on-line at room temperature in a flow-injection system and is immobilized on a weakly acidic cation-exchange resin packed in a flow cell. Optimum experimental conditions and analytical performance are discussed in detail. The sensor response for ciprofloxacin was linear, from 1.5 × 10-6 to 2.0 × 10-5M with a relative standard deviation of 2.5% (n=10) and a detection limit of 1.1 × 10-7M. The effect of possible interferences on sensor response was studied. The sensor was successfully tested for the determination of ciprofloxacin in pharmaceutical formulations.
CITATION STYLE
Cuenca-Trujillo, R. M., Ayora-Cañada, M. J., & Molina-Díaz, A. (2002). Determination of ciprofloxacin with a room-temperature phosphorescence flow-through sensor based on lanthanide-sensitized luminescence. Journal of AOAC International, 85(6), 1268–1272. https://doi.org/10.1093/jaoac/85.6.1268
Mendeley helps you to discover research relevant for your work.