A prophage in diabetic foot ulcer-colonizing staphylococcus aureus impairs invasiveness by limiting intracellular growth

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Abstract

The mechanisms that drive the transition from commensality to invasiveness in Staphylococcus aureus are poorly understood. We recently reported that >50% of S. aureus isolates from uninfected diabetic foot ulcers in French patients harbor a prophage, ROSA-like, that is absent from invasive isolates from diabetic foot infections, including osteomyelitis. Here we show that the ROSA-like insertion abolishes the ability of S. aureus to replicate within osteoblasts, the bone-forming cells, greatly reducing damage to infected cells. These results unravel an important mechanism by which particular S. aureus strains are maintained in a commensal state in diabetic foot ulcers.

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Rasigade, J. P., Dunyach-Rémy, C., Sapin, A., Messad, N., Trouillet-Assant, S., Dupieux, C., … Laurent, F. (2016). A prophage in diabetic foot ulcer-colonizing staphylococcus aureus impairs invasiveness by limiting intracellular growth. Journal of Infectious Diseases, 214(10), 1605–1608. https://doi.org/10.1093/infdis/jiw432

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