Non-coding RNAs and drug-induced liver injury

Abstract

Currently, more and more clinical cases of drug-induced liver injury (DILI) are increasing that may lead to acute liver failure and even death. It has been reported that DILI is the main cause of clinical drugs withdrawal, which results in a bad impact on the treatment of many diseases. So far there are still no effective monitoring means and therapeutic approaches for DILI. Nowadays many types of research on noncoding RNAs (ncRNAs), mainly including microRNAs, lncRNAs, and circRNAs, are interesting and have significant effects on lots of diseases, such as diagnostic biomarkers and treatment methods. This article mainly reviews concerning the ncRNAs in DILI to find the new sights of diagnosis and treatments in DILI.