Alterations of host cell ubiquitination machinery by pathogenic bacteria

  • Alomairi J
  • Bonacci T
  • Ghigo E
  • et al.
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Abstract

Response of immune and non-immune cells to pathogens infections is a very dynamic process. It involves the activation/modulation of many pathways leading to actin remodeling, membrane engulfing, phagocytosis, vesicle trafficking, phagolysosome formation, aiming at the destruction of the intruder. These sophisticated and rapid mechanisms rely on post-translational modifications (PTMs) of key host cells' factors, and bacteria have developed various strategies to manipulate them to favor their survival. Among these important PTMs, ubiquitination has emerged as a major mediator/modulator/regulator of host cells response to infections that pathogens have also learned to use for their own benefit. In this mini-review, we summarize our current knowledge about the normal functions of ubiquitination during host cell infection, and we detail its hijacking by model pathogens to escape clearance and to proliferate.

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Alomairi, J., Bonacci, T., Ghigo, E., & Soubeyran, P. (2015). Alterations of host cell ubiquitination machinery by pathogenic bacteria. Frontiers in Cellular and Infection Microbiology, 5. https://doi.org/10.3389/fcimb.2015.00017

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