Immunosuppressants, including anti-TNFalpha antibodies, have remarkable effects in rheumatoid arthritis; however, they increase infectious events. The present study was designed to examine the effects and immunological change of action of altered peptide ligands (APLs) on glucose-6-phosphate isomerase (GPI) peptide-induced arthritis.
Iwanami, K., Matsumoto, I., Yoshiga, Y., Inoue, A., Kondo, Y., Yamamoto, K., … Sumida, T. (2009). Altered peptide ligands inhibit arthritis induced by glucose-6-phosphate isomerase peptide. Arthritis Research and Therapy, 11(6). https://doi.org/10.1186/ar2854