A silyl glyoxylate three-component-coupling methodology has been exploited to achieve a formal synthesis, an analogue to an intermediate in a distinct formal synthetic route, and a third (unique) approach to the natural product alternaric acid. Highlighted in this study is the versatility of silyl glyoxylates to engage a variety of nucleophile and electrophile pairs to provide wide latitude in the approach to complex molecule synthesis.
Slade, M. C., & Johnson, J. S. (2013). Alternaric acid: Formal synthesis and related studies. Beilstein Journal of Organic Chemistry, 9, 166–172. https://doi.org/10.3762/bjoc.9.19