Analysis of solvent tolerance in Pseudomonas putida DOT-T1E based on its genome sequence and a collection of mutants

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Abstract

Pseudomonas putida strains are prevalent in a variety of pristine and polluted environments. The genome of the solvent-tolerant P. putida strain DOT-T1E which thrives in the presence of high concentrations of monoaromatic hydrocarbons, contains a circular 6.3 Mbp chromosome and a 133 kbp plasmid. Omics information has been used to identify the genes and proteins involved in solvent tolerance in this bacterium. This strain uses a multifactorial response that involves fine-tuning of lipid fluidity, activation of a general stress-response system, enhanced energy generation, and induction of specific efflux pumps that extrude solvents to the medium. Local and global transcriptional regulators participate in a complex network of metabolic functions, acting as the decision makers in the response to solvents. © 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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Udaondo, Z., Duque, E., Fernández, M., Molina, L., Torre, J. D. L., Bernal, P., … Ramos, J. L. (2012). Analysis of solvent tolerance in Pseudomonas putida DOT-T1E based on its genome sequence and a collection of mutants. In FEBS Letters (Vol. 586, pp. 2932–2938). https://doi.org/10.1016/j.febslet.2012.07.031

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