An analytic and systematic framework for estimating metabolic flux ratios from 13C tracer experiments

37Citations
Citations of this article
105Readers
Mendeley users who have this article in their library.

Abstract

Metabolic fluxes provide invaluable insight on the integrated response of a cell to environmental stimuli or genetic modifications. Current computational methods for estimating the metabolic fluxes from 13C isotopomer measurement data rely either on manual derivation of analytic equations constraining the fluxes or on the numerical solution of a highly nonlinear system of isotopomer balance equations. In the first approach, analytic equations have to be tediously derived for each organism, substrate or labelling pattern, while in the second approach, the global nature of an optimum solution is difficult to prove and comprehensive measurements of external fluxes to augment the 13C isotopomer data are typically needed. PMID: 18534038

Cite

CITATION STYLE

APA

Rantanen, A., Rousu, J., Jouhten, P., Zamboni, N., Maaheimo, H., & Ukkonen, E. (2008). An analytic and systematic framework for estimating metabolic flux ratios from 13C tracer experiments. BMC Bioinformatics, 9. https://doi.org/10.1186/1471-2105-9-266

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free