Objective: To determine whether rectally administered misoprostol can induce intestinal motility compared with oxytocin infusion when used to prevent primary postpartum hemorrhage after cesarean delivery. Methods: In a prospective randomized double-blind study in Nigeria, 218 parturients undergoing cesarean deliverywho had risk factors for primary postpartumhemorrhagewere enrolled between July 1, 2010, and March 31, 2011. Participants received 600 ?g of rectal misoprostol or 20 intravenous units of oxytocin for 4 hours after surgery. The primary outcome was time until passage of flatus. Adverse effects, need for additional analgesic, and length of hospital stay were also assessed. Results: The misoprostol group had a significantly shorter mean postoperative interval to passage of flatus (20.27±7.77 hours versus 38.34±10.98 hours; Pb0.001) and ommencement of regular diet (21.08±7.69 hours versus 39.13±10.94 hours; Pb0.001). Gastrointestinal adverse effects were more frequent, albeit not significantly, in the misoprostol group: nausea, 6.4% versus 1.8%; vomiting, 7.3% versus 2.8%; and abdominal distension, 3.7% versus 2.8%. The need for additional analgesicwas the same in the 2 groups. Conclusion: After cesarean delivery, rectal misoprostol had the added benefit of inducing intestinal motility. Misoprostol might be considered in a clinical setting where postoperative ileus is anticipated. © 2013 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.
Johnson, T. R. B. (2013). Announcing the winner of the John J. Sciarra IJGO Prize Paper Award for 2012. International Journal of Gynecology and Obstetrics. John Wiley and Sons Ltd. https://doi.org/10.1016/j.ijgo.2013.02.009