Anticancer activity of Aristolochia ringens Vahl. (Aristolochiaceae)

Citations of this article
Mendeley users who have this article in their library.


Cancer is a leading cause of death worldwide and sustained focus is on the discovery and development of newer and better tolerated anticancer drugs especially from plants. The sulforhodamine B (SRB) in vitro cytotoxicity assay, sarcoma-180 (S-180) ascites and solid tumor, and L1210 lymphoid leukemia in vivo models were used to investigate the anticancer activity of root extracts of Aristolochia ringens Vahl. (Aristolochiaceae; mə dou líng). AR-A001 (IC50 values of 20 μg/mL, 22 μg/mL, 3 μg/mL, and 24 μg/mL for A549, HCT-116, PC3, and THP-1 cell lines, respectively), andAR-A004 (IC50 values of 26 μg/mL,19.5 μg/mL,12 μg/mL, 28 μg/mL, 30 μg/mL, and 22 μg/mL for A549, HCT-116, PC3, A431, HeLa, and THP-1, respectively), were observed to be significantlyactive in vitro. Potencywashighest withAR-A001 andAR-A004 for PC3withIC50values of 3 μg/mL and 12 μg/mL, respectively. AR-A001 and AR-A004 produced significant (p < 0.05e0.001) dose-dependent inhibition of tumor growth in the S-180 ascites model with peak effects produced at the highest dose of 120mg/kg. Inhibitionvalueswere 79.51%and89.98%forAR-A001andAR-A004, respectively. Inthe S-180solid tumormodel, the inhibition of tumor growth was 29.45% and 50.50% for AR-A001 (120mg/kg) and AR-A004 (110 mg/kg), respectively, compared to 50.18% for 5-fluorouracil (5-FU; 20 mg/kg). AR-A001 and AR-A004 were also significantly active in the leukemia model with 211.11% and 155.56% increase in mean survival time (MST) compared to a value of 211.11% for 5-FU. In conclusion, the ethanolic (AR-A001) and dichloromethane: methanol (AR-A004) root extracts of AR possess significant anticancer activities in vitro and in vivo.




Akindele, A. J., Wani, Z., Mahajan, G., Sharma, S., Aigbe, F. R., Satti, N., … Mondhe, D. M. (2015). Anticancer activity of Aristolochia ringens Vahl. (Aristolochiaceae). Journal of Traditional and Complementary Medicine, 5(1), 35–41.

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free