Antigen processing: HLA-DO –  a hitchhiking inhibitor of HLA-DM

  • Jensen P
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Abstract

Recent studies have revealed that the conserved major histocompatibility complex class II molecule, HLA-DO, inhibits the class II antigen-processing pathway. HLA-DO, expressed in only a subset of antigen-presenting cells, binds HLA-DM and blocks HLA-DM-catalyzed peptide loading of class II molecules.

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Jensen, P. E. (2004). Antigen processing: HLA-DO –  a hitchhiking inhibitor of HLA-DM. Current Biology, 8(4), R128–R131. https://doi.org/10.1016/s0960-9822(98)70988-1

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