A confocal fluorescence microscope was used to study the antigen receptor-mediated calcium signals in B cells. Anti-IgD binding to B lymphoma cells (BAL17) increased the intracellular calcium concentration with short lag times. Confocal fluorescence images of the fluo-3-loaded BAL17 cells showed that the intracellular calcium ion concentrations increased non-homogeneously, suggesting that the calcium signals transferred not only to the cytoplasm but also to the nucleus. © 1991.
Yamada, H., Mizuguchi, J., & Nakanishi, M. (1991). Antigen receptor-mediated calcium signals in B cells as revealed by confocal fluorescence microscopy. FEBS Letters, 284(2), 249–251. https://doi.org/10.1016/0014-5793(91)80696-Z