Anti-inflammatory and mycobacterial activity of leaf extracts of Coleonema album

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Abstract

Acetone and ethanolic leaf extracts of Coleonema album were screened for anti-inflammatory and antimycobacterial activity using the cyclooxygenase (COX-1 and COX-2) and broth micro-dilution assays against Mycobacterium aurum A+ respectively. In the cyclooxygenase assays, all extracts showed preferential activity against COX-2 with an IC50 value of 40 μg/ml for the acetone extract. The same extract had an IC50 value of 225 μg/ml against COX-1 with a COX-2/COX-1 selectivity ratio of 0.17. In the antimycobacterial test all extracts showed moderate activity against M. aurum with an MIC value of 3.1 mg/ml. The results suggest more in depth investigations into the anti-inflammatory compounds present in C. album. © 2007 SAAB.

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Eldeen, I. M. S., & Van Staden, J. (2008). Anti-inflammatory and mycobacterial activity of leaf extracts of Coleonema album. South African Journal of Botany, 74(2), 345–347. https://doi.org/10.1016/j.sajb.2007.11.008

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