The antioxidant action of tamoxifen and its metabolites Inhibition of lipid peroxidation

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Abstract

The anti-oestrogen drug tamoxifen is an inhibitor of lipid peroxidation in rat liver microsomes and in phospholipid liposomes. Its cis isomer and N-desmethyl form are weaker inhibitors, but 4-hydroxytamoxifen is much more powerful. It is possible that the antioxidant property of tamoxifen might contribute to its biological actions. © 1990.

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Wiseman, H., Laughton, M. J., Arnstein, H. R. V., Cannon, M., & Halliwell, B. (1990). The antioxidant action of tamoxifen and its metabolites Inhibition of lipid peroxidation. FEBS Letters, 263(2), 192–194. https://doi.org/10.1016/0014-5793(90)81371-T

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