Antioxidant and a-glucosidase inhibitory activity of Adina rubella Hance in vitro

  • Zhang Y
Citations of this article
Mendeley users who have this article in their library.


Antioxidant activity of extracts from Adina rubella Hance (AR) was evaluated using 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and 2,2′-azino-bis (3-ethylbenzothiazoline)-6-sulphonic acid diamonium salt (ABTS) radical scavenge and ferric reducing antioxidant power assay (FRAP) with BHT (2,6-Di-tert-butyl-4-methyiphenol) as positive control, and α-glucosidase inhibitory activity assay of AR extracts with acarbose as positive control in vitro. DPPH radical scavenging activity was observed in ethyl acetate extract (AREA) and n-butanol extract (ARBU). Their IC 50 values were 21.63 and 23.16 µg/mL, respectively, slightly weaker than that of BHT (IC 50 = 18.71 µg/mL). ABTS radical scavenging activity of AREA (IC 50 = 17.25 µg/mL) was higher than that of petroleum ether extract (ARPE) and ARBU (IC 50 = 25.73 and 20.64 µg/mL, respectively), but they were weaker than that of BHT (IC 50 = 7.72 µg/mL). Ferric reducing antioxidant power for ARPE, ARBU and TEAC values were 1649.6 ± 16.09 and 1734.27 ± 68.53 μmol TE/g, respectively, and was higher than that of BHT with TEAC value of 1581.68 ± 97.41 μmol TE/g. AREA (IC 50 = 862.2 μg/mL) had the best α-glycosidase inhibitory activity, followed by ARBU (IC 50 = 924.9 μg/mL) and ARPE (IC 50 = 994.0 μg/mL). Their inhibitory activity was higher than that of acarbose (IC 50 = 1103.01 µg/mL) as positive control. Results indicated that antioxidant and α-glycosidase inhibitory activity of AREA were better than that ARPE and ARBU in vitro.




Zhang, Y. (2014). Antioxidant and a-glucosidase inhibitory activity of Adina rubella Hance in vitro. African Journal of Pharmacy and Pharmacology, 6(41), 2888–2894.

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free