Antioxidant effects of the combination of conjugated linoleic acid and phytosterol supplementation in Sprague-Dawley rats

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Abstract

The aim of this study was to investigate the effects of dietary conjugated linoleic acid (CLA) and phytosterol supplementation and their combination on antioxidant enzyme activities and biomarkers of lipid peroxidation in healthy rats. Forty male Sprague-Dawley rats were divided into five groups and received diets supplemented with 2% of soybean oil (group S), safflower oil (group LA) (control), a mixture of c9,t11 and t10,c12 CLA (group CLA), phytosterols (group P) and a mixture of CLA and phytosterols (group CLA. +. P) for 9. weeks. Plasma and hepatic indicators of lipid autoxidation and plasma antioxidant enzymes activities were determined. The supplementation with the mixture of CLA and phytosterols (CLA. +. P) did not alter food intake, weight gain, plasma malondialdehyde (MDA) and glutathione (GSH) values, superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione reductase (GRd) activities (. P>. 0.05). The supplementation with CLA significantly increased plasma catalase (CAT) activity (3.7-fold) and plasma 8-isoprostane values (60%) compared to S group (. P

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Marineli, R. da S., Marques, A. y.Castro, Furlan, C. P. B., & Maróstica, M. R. (2012). Antioxidant effects of the combination of conjugated linoleic acid and phytosterol supplementation in Sprague-Dawley rats. Food Research International, 49(1), 487–493. https://doi.org/10.1016/j.foodres.2012.07.022

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