Background & aims: Plasma antioxidant status after stroke is altered due to oxidative stress. We examined the antioxidant status after stroke and its association with survival in elderly with differing nutritional treatments. Methods: Acute stroke patients (>65 years) at nutritional risk were randomized to individualized, energy- and protein supplementation (intervention, n = 81) aiming to prevent undernutrition, or routine nutritional care (control, n = 85) during hospital stay. Plasma vitamin C, alpha-tocopherol, total carotenoids and glutathione redox potential were measured at study entry (baseline), after one week and after three months. This study is registered with ClinicalTrials.gov, number NCT00163007. Results: In both study groups, high baseline plasma glutathione (GSH) reducing capacity reduced adjusted all-cause mortality risk with almost 50% compared to low GSH reducing capacity (P = 0.02) after a mean follow-up time of 25 months. Mortality risk in the intervention group was reduced in those with either the highest GSH reducing capacity (relative risk 0.39, P = 0.02) or the highest total carotenoids (relative risk 0.35, P = 0.03) compared to lowest antioxidant status. Conclusions: Higher antioxidant status may improve survival after stroke in patients at nutritional risk. Energy- and protein supplementation might further reduce mortality risk, at least in part due to improved nutritional intake. © 2011 European Society for Clinical Nutrition and Metabolism.
Ha, L., Sakhi, A. K., Bøhn, S. K., Flekkøy, K., Blomhoff, R., Iversen, P. O., & Hauge, T. (2011). Antioxidant status after an acute stroke and the association with survival in elderly at nutritional risk. E-SPEN, 6(3). https://doi.org/10.1016/j.eclnm.2011.02.004