Apoptosis and expression of argyrophilic nucleolus organizer regions in epithelial neoplasms of the larynx

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Abstract

Introduction: Occurrence of apoptosis and expression of proliferative markers are powerful tools to establish a prognosis in the follow-up of cancer. Objective: To evaluate the growth fraction in papillomas and laryngeal squamous cell carcinomas with three degrees of differentiation through apoptosis and the expression of nucleolus organizer regions. Methods: Retrospective study from which paraffin material was submitted to microtomy and hematoxylin-eosin and silver staining. Stained slides were used to quantify the apoptotic index and the number of nucleolus organizer regions by morphometry. Results: Apoptosis was significantly more frequent in well differentiated carcinomas and in papillomas, and a higher growth fraction of expressed nucleolus organizer regions and cells that expressed a greater than average number of nucleolus organizer regions were more frequently noted in undifferentiated carcinomas. Conclusions: Thus, it was possible to verify that a high apoptotic index was associated with a lower chance of tumor differentiation in carcinomas, while a greater number of total nucleolus organizer regions, cells expressing nucleolus organizer regions above average and a higher growth fraction were associated with greater likelihood of abnormal cell proliferation and increased tumor differentiation.

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Ribeiro, C. V., Vasconcelos, A. C., & Andrade Filho, J. de S. (2015). Apoptosis and expression of argyrophilic nucleolus organizer regions in epithelial neoplasms of the larynx. Brazilian Journal of Otorhinolaryngology, 81(2), 158–166. https://doi.org/10.1016/j.bjorl.2014.12.003

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