Apoptosis repressor with caspase recruitment domain (ARC) inhibits myogenic differentiation

17Citations
Citations of this article
14Readers
Mendeley users who have this article in their library.

Abstract

Apoptosis repressor with caspase recruitment domain (ARC), an anti-apoptotic protein, is highly expressed in differentiated heart and skeletal muscle. Apoptosis and differentiation share numerous common pathways; therefore, we examined the impact of ARC on H9c2-myoblast differentiation. We demonstrate that ARC expression levels increase and stabilize upon differentiation. ARC-overexpression in pre-differentiated H9c2-cells suppresses differentiation; indicated by increased myotube formation, nuclear fusion and expression of the differentiation markers myogenin and troponin-T. ARC-overexpression inhibited myoblast differentiation associated caspase-3 activation, suggesting ARC inhibits myogenic differentiation through caspase inhibition. In summary, we show a novel role for ARC in the regulation of muscle differentiation. © 2007 Federation of European Biochemical Societies.

Cite

CITATION STYLE

APA

Hunter, A. L., Zhang, J., Chen, S. C., Si, X., Wong, B., Ekhterae, D., … Granville, D. J. (2007). Apoptosis repressor with caspase recruitment domain (ARC) inhibits myogenic differentiation. FEBS Letters, 581(5), 879–884. https://doi.org/10.1016/j.febslet.2007.01.050

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free