Aprepitant (EMEND) is the first commercially available drug from a new class of agents, the Substance P/neurokinin NK-1 receptor antagonists. Aprepitant is indicated for prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV) associated with highly emetogenic chemotherapy in adults. Its ability to antagonize the effects of Substance P has lead to greater understanding of the pathophysiology of nausea and vomiting. Its broad range of activity against a wide variety of central and peripheral emetogenic stimuli make it potentially useful in non-chemotherapy related nausea and vomiting. © 2005 by The Haworth Press, Inc. All rights reserved.
CITATION STYLE
Prommer, E. (2005). Aprepitant (EMEND): The role of substance P in nausea and vomiting. Journal of Pain and Palliative Care Pharmacotherapy. https://doi.org/10.1300/J354v19n03_06
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